Statin use and cancer risk: a comprehensive review
Open Access
- 9 April 2010
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Safety
- Vol. 9 (4), 603-621
- https://doi.org/10.1517/14740331003662620
Abstract
Importance of the field: HMG-CoA inhibitors (statins), a class of drugs that reduce cholesterol, are used to manage and prevent coronary heart disease. They are among the most commonly prescribed drugs worldwide. Contrary to early concerns over the carcinogenicity of statins, a growing body of evidence suggests statins may in fact have a chemopreventive potential against cancer. Areas covered in this review: In this paper, we review evidence on the association between statin use and cancer risk. Specifically, we report on clinical trials and observational studies that measured all cancer or site-specific cancers of the breast, colorectal, lung, prostate and reproductive organs associated with statin use. What the reader will gain: An understanding of the evidence, including strengths and limitations, to support an association between statins and cancer. Information on the current state of the field and future directions are also discussed. Take home message: Few strong or consistent associations between statins and cancer incidence overall or for any of the sites reviewed were detected. Data for any effects of statins on cancer prognosis and secondary prevention are lacking; with the exception of consistent evidence that statins are associated with reduced risk of advanced/aggressive prostate cancer. Statins appear safe in relation to cancer risk but any chemopreventive effect in humans remains to be established and should not be recommended outside the context of clinical trials. It is encouraging that numerous trials are ongoing. The prospect of reducing the incidence and burden of some of the most prevalent cancers with safe, affordable and tolerable medication that already reduces the risk of the leading cause of death and cardiovascular disease warrants further exploration in clinical trials and observational studies of prognosis and survival.Keywords
This publication has 108 references indexed in Scilit:
- Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trialsBritish Journal of Clinical Pharmacology, 2008
- Statin use and female reproductive organ cancer risk in a large population-based settingCancer Causes & Control, 2008
- Statin Use and Risk of Prostate Cancer: Results from a Population-based Epidemiologic StudyAmerican Journal of Epidemiology, 2008
- Statins and Cancer RiskAmerican Journal Of Medicine, 2008
- Statin use and prostate cancer risk in a large population-based settingCancer Causes & Control, 2008
- The Association Between Statins and Cancer Incidence in a Veterans PopulationJNCI Journal of the National Cancer Institute, 2008
- Post-diagnosis statin use and breast cancer recurrence in a prospective cohort study of early stage breast cancer survivorsBreast Cancer Research and Treatment, 2007
- Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studiesThe Lancet, 2007
- Statins and cancer preventionNature Reviews Cancer, 2005
- HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosisLeukemia, 2002