Emergence of adhfrMutation Conferring High‐Level Drug Resistance inPlasmodium falciparumPopulations from Southwest Uganda
Open Access
- 1 June 2008
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 197 (11), 1598-1604
- https://doi.org/10.1086/587845
Abstract
The S108N, C59R, and N51I mutations in the Plasmodium falciparum gene that encodes dihydrofolate reductase, dhfr, confer resistance to pyrimethamineKeywords
This publication has 64 references indexed in Scilit:
- Antifolate Resistance inPlasmodium falciparum:Multiple Origins and Identification of NoveldhfrAllelesThe Journal of Infectious Diseases, 2006
- Geographic Differences in Antimalarial Drug Efficacy in Uganda Are Explained by Differences in Endemicity and Not by Known Molecular Markers of Drug ResistanceThe Journal of Infectious Diseases, 2006
- FREQUENCY DISTRIBUTION OF ANTIMALARIAL DRUG-RESISTANT ALLELES AMONG ISOLATES OF PLASMODIUM FALCIPARUM IN BANGUI, CENTRAL AFRICAN REPUBLICThe American Journal of Tropical Medicine and Hygiene, 2006
- Mutations Associated with Sulfadoxine-Pyrimethamine and Chlorproguanil Resistance in Plasmodium falciparum Isolates from Blantyre, MalawiAntimicrobial Agents and Chemotherapy, 2005
- Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?Transactions of the Royal Society of Tropical Medicine and Hygiene, 2005
- Artesunate–dapsone–proguanil treatment of falciparum malaria: genotypic determinants of therapeutic responseTransactions of the Royal Society of Tropical Medicine and Hygiene, 2005
- Relationship between age, molecular markers, and response to sulphadoxine–pyrimethamine treatment in Kampala, UgandaTropical Medicine & International Health, 2004
- Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from TanzaniaTransactions of the Royal Society of Tropical Medicine and Hygiene, 2002
- Polyclonal Plasmodium falciparum malaria in travelers and selection of antifolate mutations after proguanil prophylaxis.The American Journal of Tropical Medicine and Hygiene, 2002
- Advances in the study of Afrotropical vectorsPathogens and Global Health, 1997