Barbiturate-Enhanced Detection of Brain Lesions by Carbon-14-Labeled 2-Deoxyglucose Autoradiography
- 18 February 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4586), 879-881
- https://doi.org/10.1126/science.6823556
Abstract
Cerebral glucose metabolism in rats was examined 1 week after the production by ibotenic acid of unilateral striatal lesions. The incorporation of carbon-14-labeled deoxyglucose decreased within the lesion but much less than that of carbon-14-labeled glucose. Barbiturate anesthesia caused a reversal of the asymmetric striatal deoxyglucose labeling, such that the lesioned striatum retained more tracer than the contralateral side. The combined use of barbiturates and radiolabeled deoxyglucose may enhance the identification of recent brain infarction in experimental animals and in man.This publication has 18 references indexed in Scilit:
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