Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man
Open Access
- 1 April 1969
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 48 (4), 745-757
- https://doi.org/10.1172/jci106032
Abstract
Intravenous administration of porcine secretin or pancreozymin or synthetic human gastrin II resulted in raised increments in serum immunoreactive insulin during intravenous infusion of glucose in normal man. Enhancement of serum immunoreactive insulin by each hormone was associated with accelerated disposal of glucose. In response to prolonged intravenous infusion of arginine with pancreozymin there was a maintained rise in immunoreactive insulin and glucagon-like immunoreactivity in the blood. These effects of pancreozymin and arginine were not reproduced with secretin and arginine, and may have been due to the stimulation of glucagon secretion together with insulin by pancreozymin. Enteric infusion of hydrochloric acid, or stimulation of gastric acid secretion by betazole, presumed to cause release of endogenous secretin, led to enhancement of insulin secretion during intravenous infusion of glucose. Enteric infusion of arginine, presumed to cause release of endogenous pancreozymin, led to a rise in serum immunoreactive insulin not attributable to effects of circulating glucose and amino acids. It is concluded that secretin and pancreozymin released in response to physiological stimuli contribute to stimulation of the endocrine pancreas after ingestion of food.Keywords
This publication has 26 references indexed in Scilit:
- FAILURE OF ENDOGENOUS STIMULATION OF SECRETIN AND PANCREOZYMIN RELEASE TO INFLUENCE SERUM-INSULINThe Lancet, 1968
- Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucoseJCI Insight, 1968
- Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*JCI Insight, 1967
- INTRADUODENAL GLUCOSE INFUSION AND PANCREATIC SECRETION IN MANThe Lancet, 1967
- Intestinal hormones and plasma insulin: an insulinotropic action of secretin.BMJ, 1967
- Basal Plasma Glucagon Levels of Man*JCI Insight, 1967
- The Effects of Secretin, Pancreozymin, and Gastrin on Insulin and Glucagon Secretion in Anesthetized Dogs *JCI Insight, 1967
- INTESTINAL HORMONES AND PLASMA-INSULINThe Lancet, 1966
- STIMULATION OF GLUCAGON SECRETION BY ORAL GLUCOSEThe Lancet, 1965
- AN INTESTINAL HORMONE AFFECTING GLUCOSE DISPOSAL IN MANThe Lancet, 1964