The estimated prevalence and incidence of late stage age related macular degeneration in the UK
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Open Access
- 13 February 2012
- journal article
- laboratory science
- Published by BMJ in British Journal of Ophthalmology
- Vol. 96 (5), 752-756
- https://doi.org/10.1136/bjophthalmol-2011-301109
Abstract
Background UK estimates of age related macular degeneration (AMD) occurrence vary. Aims To estimate prevalence, number and incidence of AMD by type in the UK population aged ≥50 years. Methods Age-specific prevalence rates of AMD obtained from a Bayesian meta-analysis of AMD prevalence were applied to UK 2007–2009 population data. Incidence was estimated from modelled age-specific prevalence. Results Overall prevalence of late AMD was 2.4% (95% credible interval (CrI) 1.7% to 3.3%), equivalent to 513 000 cases (95% CrI 363 000 to 699 000); estimated to increase to 679 000 cases by 2020. Prevalences were 4.8% aged ≥65 years, 12.2% aged ≥80 years. Geographical atrophy (GA) prevalence rates were 1.3% (95% CrI 0.9% to 1.9%), 2.6% (95% CrI 1.8% to 3.7%) and 6.7% (95% CrI 4.6% to 9.6%); neovascular AMD (NVAMD) 1.2% (95% CrI 0.9% to 1.7%), 2.5% (95% CrI 1.8% to 3.4%) and 6.3% (95% CrI 4.5% to 8.6%), respectively. The estimated number of prevalent cases of late AMD were 60% higher in women versus men (314 000 cases in women, 192 000 men). Annual incidence of late AMD, GA and NVAMD per 1000 women was 4.1 (95% CrI 2.4% to 6.8%), 2.4 (95% CrI 1.5% to 3.9%) and 2.3 (95% CrI 1.4% to 4.0%); in men 2.6 (95% CrI 1.5% to 4.4%), 1.7 (95% CrI 1.0% to 2.8%) and 1.4 (95% CrI 0.8% to 2.4%), respectively. 71 000 new cases of late AMD were estimated per year. Conclusions These estimates will guide health and social service provision for those with late AMD and enable estimation of the cost of introducing new treatments.Keywords
This publication has 31 references indexed in Scilit:
- Age and Gender Variations in Age-related Macular Degeneration Prevalence in Populations of European Ancestry: A Meta-analysisOphthalmology, 2012
- Prevalence of Age-Related Macular Degeneration in the United StatesAmerican Journal of Ophthalmology, 2004
- The Risk and Natural Course of Age-Related MaculopathyAmerican Journal of Ophthalmology, 2003
- How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom?British Journal of Ophthalmology, 2003
- Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluationHealth Technology Assessment, 2003
- REVIEW: Epidemiology of age-related maculopathy: a reviewEuropean Journal of Epidemiology, 2003
- Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye studyOphthalmology, 2002
- Five-year incidence of age-related maculopathy lesions: The blue mountains eye studyOphthalmology, 2002
- Photodynamic therapy in the treatment of subfoveal choroidal neovascularisationEye, 2001
- ESTIMATING INCIDENCE FROM AGE-SPECIFIC PREVALENCE IN GLAUCOMAAmerican Journal of Epidemiology, 1981