Genetic Variation in the Promoter Region of the .BETA.2 Bradykinin Receptor Gene Is Associated with Essential Hypertension in a Chinese Han Population.
Open Access
- 1 January 2001
- journal article
- Published by Japanese Society of Hypertension in Hypertension Research
- Vol. 24 (3), 299-302
- https://doi.org/10.1291/hypres.24.299
Abstract
The present study examined whether a genetic variant (−58T/C) in the promoter region of the human β2 bradykinin receptor gene was genetically involved in essential hypertension. Chinese hypertensive subjects (n=120) and normotensive controls (n=98; sex- and age-matched with hypertensive) were recruited from the outpatients of Fu Wai hospital. Distribution of the −58T/C polymorphism was determined in patients and controls by means of PCR, SSCP, cloning and sequencing. The allelic frequencies were 0.56 for the C allele and 0.44 for the T allele in hypertensive subjects, and 0.46 for the C allele and 0.54 for the T allele in normotensive subjects. The allelic frequencies were in Hardy-Weinberg equilibrium. Significant differences between hypertensive and normotensive subjects were seen in the genotypes distribution (p=0.045) and allelic frequencies (p=0.033). These results suggested that −58C allele of the human β2 bradykinin receptor gene may be an independent risk factor for essential hypertension in the Chinese Han population. (Hypertens Res 2001; 24: 299-302)Keywords
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