Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma
- 11 September 2007
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 139 (1), 51-54
- https://doi.org/10.1111/j.1365-2141.2007.06750.x
Abstract
The combination of fluorescence in situ hybridization with cytoplasmic light chain detection identified chromosome 1p21 deletion in 18 (20%) of 87 patients with multiple myeloma. 1p21 deletion was associated with higher serum calcium level, 13q deletion, and t(4;14). Patients with 1p21 deletions had a significantly shorter progression-free survival (PFS) (median 10.5 vs. 22.3 months, P = 0.0002) and shorter overall survival (OS) (median 33.9 months vs. not reached, P = 0.002) than those without 1p21 deletions. On multivariate analysis, which included deletions of 13q, TP53, t(4;14) and CKS1B amplification, 1p21 deletion remained as an independent risk factor for PFS (P = 0.01) and OS (P = 0.04).Keywords
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