Long term follow-up study to evaluate immunogenicity and safety of a single dose of live attenuated hepatitis a vaccine in children
Open Access
- 21 January 2015
- journal article
- Published by Taylor & Francis Ltd in Human Vaccines & Immunotherapeutics
- Vol. 11 (5), 1147-1152
- https://doi.org/10.4161/21645515.2014.979646
Abstract
Worldwide, viral hepatitis continues to be a cause of considerable morbidity and mortality. Mass immunization with a single dose of live attenuated HAV has been shown to significantly reduce disease burden in the community. This was a phase IV, 5-year follow up study carried out at 4 centers (Kolkata, Delhi, Mumbai and Chennai) across India. The subjects with antibody titer 20 mIU/mL). The seroconversion rates considering seroprotection levels of anti-HAV antibody titer >20 mIU/mL, following vaccination starting from 6 weeks, 6 months, 12 months, 24 months, 36 months, 48 months and 60 months were 95.1%, 97.9%, 98.3%, 96.2%, 97.8%, 92.6% and 97.3%, respectively. The geometric mean concentration (GMC) over the years increased from 64.9 mIU/mL at 6 weeks to 38.1 mIU/mL and 135.2 mIU/mL at 6 months and 12 months, respectively and was maintained at 127.1 mIU/mL at 60 months. In conclusion, the result of this 5-year follow up study showed that the single dose of live attenuated vaccine is well tolerated and provides long-term immunogenicity in healthy Indian children.Keywords
This publication has 24 references indexed in Scilit:
- WHO position paper on hepatitis A vaccines: June 2012—RecommendationsVaccine, 2013
- Relation Between Serum Total Cholesterol Level and Cardiovascular Disease Stratified by Sex and Age Group: A Pooled Analysis of 65 594 Individuals From 10 Cohort Studies in JapanJournal of the American Heart Association, 2012
- Persistence of hepatitis A vaccine induced seropositivity in infants and young children by maternal antibody status: 10-year follow-upHepatology, 2012
- Hepatitis A: Epidemiology and prevention in developing countriesWorld Journal of Hepatology, 2012
- Incidence of Hepatitis A in Argentina after vaccinationJournal of Viral Hepatitis, 2008
- Long-term immunogenicity after single and booster dose of a live attenuated hepatitis A vaccine: Results from 8-year follow-upVaccine, 2007
- Immune responses of anti-HAV in children vaccinated with live attenuated and inactivated hepatitis A vaccinesVaccine, 2004
- Efficacy of Virosome Hepatitis A Vaccine in Young Children in Nicaragua: Randomized Placebo‐Controlled TrialThe Journal of Infectious Diseases, 2003
- Time course of hepatitis A antibody production after active, passive and active/passive immunisation: The results are highly dependent on the antibody test system usedJournal of Virological Methods, 1993
- Development of live, attenuated hepatitis A vaccine (H2-strain)Vaccine, 1990