Impact of Deoxynivalenol on the Intestinal Microflora of Pigs
Open Access
- 26 December 2008
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 10 (1), 1-17
- https://doi.org/10.3390/ijms10010001
Abstract
Deoxynivalenol (DON), a mycotoxin produced by some Fusarium species, is a frequent contaminant of cereal. In the present study, 24 weanling piglets received either control feed or feed naturally contaminated with DON (2.8 mg/kg) for four weeks. Consumption of contaminated feed significantly reduced the animal weight gain during the first week of the experiment, but had a moderate effect on cultivable bacteria in the pig intestine. By contrast, changes in the intestinal microflora were observed by Capillary Electrophoresis Single-Stranded Conformation Polymorphism (CE-SSCP) in DON-exposed animals, suggesting an impact of this toxin on the dynamics of intestinal bacteria communities.Keywords
This publication has 55 references indexed in Scilit:
- Diversity of the gut microbiota and eczema in early lifeClinical and Molecular Allergy, 2008
- Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: Stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial passage of commensal bacteriaToxicology and Applied Pharmacology, 2007
- Comparison of CE-SSCP and DGGE for monitoring a complex microbial community remediating mine drainageJournal of Microbiological Methods, 2007
- Dynamics of a Pig Slurry Microbial Community during Anaerobic Storage and ManagementApplied and Environmental Microbiology, 2006
- The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune responseVeterinary Immunology and Immunopathology, 2005
- Assessment of bacterial community structure in soil by polymerase chain reaction and denaturing gradient gel electrophoresis.Journal of Microbiological Methods, 1999
- An example of using mixed models and proc mixed for longitudinal dataJournal of Biopharmaceutical Statistics, 1997
- Invited Review: TOXICOLOGY OF DEOXYNIVALENOL (VOMITOXIN)Journal of Toxicology and Environmental Health, 1996
- Influence of Low-Level Exposure to Fusarium Mycotoxins on Selected Immunological and Hematological Parameters in Young SwineFundamental and Applied Toxicology, 1994
- The effects of naturally deoxynivalenol-contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigsVeterinary Research Communications, 1993