Anticancer effect of three pyrazole derivatives
- 1 September 2006
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 20 (11), 1024-1030
- https://doi.org/10.1080/14786410600921441
Abstract
The evaluation of the cytotoxic properties in vitro of three synthetic tripods containing pyrazole: N,N-bis[(3,5-dimethylpyrazol-1-yl)methyl]aniline (1); N,N-tetrakis[(3,5-dimethylpyrazol-1-yl)methyl]-para-phenylenediamine (2); and N,N-tetrakis-[(1,5-dimethylpyrazol-3-yl)methyl]-para-phenylenediamine (3), was examined for their cytotoxic activity on two tumor cell lines: P815 (murin mastocytoma) and Hep (human laryngeal carcinome). While the compound 2 shows a small cytotoxic activity, compounds 1 and 3 are more cytotoxic against both cell lines. However, this cytotoxicity is more pronounced against Hep cell line (IC50: 3.25 µg mL−1 for compound 1 and 6.92 µg mL−1 for compound 3) than P815 cell line (IC50: 17.82 µg mL−1 for compound 1 and 37.21 µg mL−1 for compound 3). Statistical analysis shows that the compound 1 is two- to threefold more cytotoxic than compound 3 (P < 0.05). Interestingly, the cytotoxicity induced by compound 1 against Hep cell line is more important than that induced by adriamycin used as a positive control.Keywords
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