Age-associated changes in Ca2+-dependent processes: Relation to hippocampal synaptic plasticity
- 1 January 1997
- journal article
- review article
- Published by Wiley in Hippocampus
- Vol. 7 (6), 602-612
- https://doi.org/10.1002/(sici)1098-1063(1997)7:6<602::aid-hipo3>3.0.co;2-g
Abstract
Altered calcium (Ca2+) homeostasis is thought to play a key role in aging and neuropathology resulting in memory deficits. Several forms of hippocampal synaptic plasticity are dependent on Ca2+, providing a potential link between altered Ca2+ homeostasis and memory deficits associated with aging. The current study reviews evidence for Ca2+ dysregulation during aging which could interact with Ca2+-dependent synaptic plasticity. The authors suggest that changes in Ca2+ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging. Hippocampus 1997;7:602–612.Keywords
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