In Vivo Induction of Apoptosis Correlating with Reduced Infectivity during Baculovirus Infection
Open Access
- 1 February 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (3), 2227-2232
- https://doi.org/10.1128/jvi.77.3.2227-2232.2003
Abstract
Spodoptera frugiperda caterpillars were infected with a mutant of Autographa californica M nucleopolyhedrovirus lacking the antiapoptotic p35 gene. Viral infectivity, replication, and spread were substantially reduced compared to that of a control revertant virus. Terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling confirmed that apoptosis occurred in mutant-infected caterpillars, thus directly correlating reduced infectivity and in vivo induction of apoptosis.This publication has 12 references indexed in Scilit:
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