The Impact of Fluoride on Ameloblasts and the Mechanisms of Enamel Fluorosis
- 25 September 2009
- journal article
- review article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 88 (10), 877-893
- https://doi.org/10.1177/0022034509343280
Abstract
Intake of excess amounts of fluoride during tooth development cause enamel fluorosis, a developmental disturbance that makes enamel more porous. In mild fluorosis, there are white opaque striations across the enamel surface, whereas in more severe cases, the porous regions increase in size, with enamel pitting, and secondary discoloration of the enamel surface. The effects of fluoride on enamel formation suggest that fluoride affects the enamel-forming cells, the ameloblasts. Studies investigating the effects of fluoride on ameloblasts and the mechanisms of fluorosis are based on in vitro cultures as well as animal models. The use of these model systems requires a biologically relevant fluoride dose, and must be carefully interpreted in relation to human tooth formation. Based on these studies, we propose that fluoride can directly affect the ameloblasts, particularly at high fluoride levels, while at lower fluoride levels, the ameloblasts may respond to local effects of fluoride on the mineralizing matrix. A new working model is presented, focused on the assumption that fluoride increases the rate of mineral formation, resulting in a greater release of protons into the forming enamel matrix.Keywords
This publication has 154 references indexed in Scilit:
- Localization and function of the anion exchanger Ae2 in developing teeth and orofacial bone in rodentsJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2009
- Detection of Dental Fluorosis-Associated Quantitative Trait Loci on Mouse Chromosomes 2 and 11Cells Tissues Organs, 2008
- The anion exchanger Ae2 is required for enamel maturation in mouse teethMatrix Biology, 2008
- JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitroMatrix Biology, 2007
- Characterization of Fluorosed Human Enamel by Color Reflectance, Ultrastructure, and Elemental CompositionCaries Research, 1995
- Fluoride and Calcium Content of Enamel Organ, Muscle, Liver and Plasma in RatsCaries Research, 1992
- Effect of Fluoride in the Apatitic Lattice on Adsorption of Enamel Proteins onto Calcium ApatitesJournal of Dental Research, 1988
- Scanning electron microscopy of fluorideinduced disturbances on the enamel surface of rat molarsEuropean Journal of Oral Sciences, 1986
- Enamel Fluorosis Related to Plasma F Levels in the RatCaries Research, 1984
- Distribution in developing rat enamel of simultaneously injected fluoride and calciumEuropean Journal of Oral Sciences, 1971