Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation
- 15 January 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5963), 331-334
- https://doi.org/10.1126/science.1179907
Abstract
Targeting Copper Clusters: Tetrathiomolybdate (TM) is a copper-depleting agent that has potential in treating copper-dependent diseases. Alvarez et al. (p. 331 , published online 26 November) used spectroscopic and structural studies to show that TM inhibits the yeast copper chaperone Atx1 by forming a TM-Cu-ATx1 complex that is stabilized by a sulfur-bridged copper-molybdenum cluster. Cluster formation prevents transfer of copper from the chaperone to target enzymes. The results provide a basis for developing drugs that target metallation pathways.Keywords
This publication has 27 references indexed in Scilit:
- Tracing Copper−Thiomolybdate Complexes in a Prospective Treatment for Wilson’s DiseaseBiochemistry, 2009
- Superoxide dismutase 1 (SOD1) is essential for H 2 O 2 -mediated oxidation and inactivation of phosphatases in growth factor signalingProceedings of the National Academy of Sciences of the United States of America, 2008
- Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell ProliferationJournal of Biological Chemistry, 2008
- Reversible precipitation of bovine serum albumin by metal ions and synthesis, structure and reactivity of new tetrathiometallate chelating agentsJournal of Inorganic Biochemistry, 2007
- How many metals does it take to fix N 2 ? A mechanistic overview of biological nitrogen fixationProceedings of the National Academy of Sciences of the United States of America, 2006
- Copper Binding by Tetrathiomolybdate Attenuates Angiogenesis and Tumor Cell Proliferation through the Inhibition of Superoxide Dismutase 1Clinical Cancer Research, 2006
- Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion ReceptorsScience, 2003
- The First Assembly of a Nest-Shaped Heterothiometallic Cluster and a Polyoxometalate Anion − Synthesis, Characterization, and Strong Third-Order Nonlinear Optical ResponseEuropean Journal of Inorganic Chemistry, 2001
- Trace elements in animalsPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1979
- Demyelination in Lambs Born of Ewes Maintained on High Intakes of Sulphate and MolybdateNature, 1960