Melanoma risk in congenital melanocytic naevi: a systematic review
Top Cited Papers
- 24 March 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 155 (1), 1-8
- https://doi.org/10.1111/j.1365-2133.2006.07218.x
Abstract
The risk of malignant melanoma in congenital melanocytic naevi (CMN) is a matter of controversial and ongoing debate.The purpose of this systematic review is to provide a careful and detailed summary of the published data, including several recently published studies.Articles on CMN (n=1424) were retrieved from Medline, 1966-October 2005. Case reports and studies lacking relevant clinical information were excluded. Only systematic collections of cases were taken into consideration. Series with fewer than 20 patients or studies with a mean follow-up of or=40 cm in diameter.The overall risk of melanoma of 0.7% in all 14 studies was lower than expected. The higher incidence of melanomas in smaller studies indicates selection bias. The melanoma risk strongly depends on the size of CMN and is highest in those naevi traditionally designated as garment naevi. The median age of 7 years at diagnosis of melanoma points to a risk maximum in childhood and adolescence. Future studies on CMN should report: (i) diameter, percentage of body surface, and localization of the CMN; (ii) percentage of naevus area removed by excision or subject to dermabrasion or other superficial treatments; (iii) mean and median age at entry into the study; (iv) mean and median follow-up time; (v) details on each melanoma case; (vi) standardized morbidity ratio of melanoma; and (vii) percentage of neurocutaneous melanosis.Keywords
This publication has 32 references indexed in Scilit:
- Outcomes and pathological review of a cohort of children with melanomaBritish Journal of Dermatology, 2005
- Large or multiple congenital melanocytic nevi: Occurrence of cutaneous melanoma in 1008 personsJournal of the American Academy of Dermatology, 2005
- Central nervous system imaging and congenital melanocytic naeviArchives of Disease in Childhood, 2001
- A study of large congenital melanocytic nevi and associated malignant melanomas: Review of cases in the New York University registry and the world literatureJournal of the American Academy of Dermatology, 1997
- Neurocutaneous melanosis: Clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosisJournal of the American Academy of Dermatology, 1996
- The risk of melanoma in patients with congenital nevi: A cohort studyJournal of the American Academy of Dermatology, 1995
- Giant pigmented nevi: Clinical, histopathologic, and therapeutic considerationsThe Journal of Pediatrics, 1992
- A prevalence survey of dermatoses in the Australian neonateJournal of the American Academy of Dermatology, 1990
- Melanomas Arising in Large Congenital Nevocytic Nevi: A Prospective StudyPediatric Dermatology, 1988
- Congenital nevocytic nevi and malignant melanomasJournal of the American Academy of Dermatology, 1979