Glycerophosphate acyltransferase activity in perfused liver of normal and hyperlipemic rats: Glucagon effect
- 1 October 1981
- journal article
- research article
- Published by Springer Science and Business Media LLC in Acta Diabetologica
- Vol. 18 (4), 357-363
- https://doi.org/10.1007/bf02042820
Abstract
Mitochondrial glycerophosphate-acyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats. A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10−5 M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.Keywords
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