The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3.
Open Access
- 1 October 1990
- journal article
- Published by Informa UK Limited in Molecular and Cellular Biology
- Vol. 10 (10), 5553-5557
- https://doi.org/10.1128/mcb.10.10.5553
Abstract
The sequence of the DIN1 gene of Saccharomyces cerevisiae is identical to RNR3, a gene encoding a DNA damage-inducible regulatory subunit of ribonucleotide reductase. Two sequence elements located upstream of DIN1 (RNR3) are homologous to putative DNA damage regulatory elements in the promoter of the reductase catalytic subunit gene, RNR2. The transcript start sites for DIN1(RNR3) have been localized, and induction by different agents has been compared with other DNA damage-regulated genes.Keywords
This publication has 15 references indexed in Scilit:
- Structure of the DNA damage-inducible gene DDR48 and evidence for its role in mutagenesis in Saccharomyces cerevisiae.Molecular and Cellular Biology, 1990
- Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.Genes & Development, 1990
- Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.Molecular and Cellular Biology, 1989
- DNA damage induction of ribonucleotide reductase.Molecular and Cellular Biology, 1989
- Expression of the yeast UB14 gene increases in response to DNA-damaging agents and in meiosis.Molecular and Cellular Biology, 1988
- Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.Molecular and Cellular Biology, 1987
- Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells.Journal of Biological Chemistry, 1985
- Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents.Molecular and Cellular Biology, 1985
- [16] Cloning regulated yeast genes from a pool of lacZ fusionsMethods in enzymology, 1983
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977