Analyzing the Effect of Weak External Transcranial Magnetic Stimulation on the Primary Dominant Frequencies of Alzheimer Patients Brain by Using MEG Recordings
Open Access
- 26 October 2021
- Vol. 57 (11), 1164
- https://doi.org/10.3390/medicina57111164
Abstract
Backround and Objectives: Alternative, non-invasive, and non-pharmaceutical options are gaining place in the battle of Alzheimer’s Disease treatment control. Lately, the magnetic stimulation of the brain is the most prevalent technique with encouraging results. The aim of this study is to establish any possible change on the Primary Dominant Frequencies (PDF) (range 2–7 Hz) of the affected brain regions in Alzheimer Disease (AD) patients after applying extremely weak Transcranial Magnetic Stimulation. Materials and Methods: For this purpose, all AD patients were scanned with the use of MagnetoEncephaloGraphy (MEG) recordings through a whole-head 122–channel MEG system. Results: Our results exerted statistically significant PDF changes due to weak TMS accompanied by rabid attenuation of clinical symptoms. Conclusion: Thus, this is the first time that a positive therapeutic effect is being demonstrated even at pico-Tesla range magnetic fields in a small clinical group of studies for AD.Keywords
Funding Information
- General Secretariat for Research and Technology (80623)
- ERGO AEBE INC, GR (80623)
This publication has 30 references indexed in Scilit:
- Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias?Alzheimer's Research & Therapy, 2014
- Magnetoencephalography: Basic principlesAnnals of Indian Academy of Neurology, 2014
- Viewpoint: Crosstalks between neurofibrillary tangles and amyloid plaque formationAgeing Research Reviews, 2012
- The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive ImpairmentCold Spring Harbor Perspectives in Medicine, 2012
- Alzheimer’s Disease – Not an Exaggeration of Healthy AgingIndian Journal of Psychological Medicine, 2011
- Neuropathology of Alzheimer's DiseaseMount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 2010
- Enkephalin Elevations Contribute to Neuronal and Behavioral Impairments in a Transgenic Mouse Model of Alzheimer's DiseaseJournal of Neuroscience, 2008
- The incidence of first‐onset psychotic symptoms and paranoid ideation in a representative population sample followed from age 70–90 years. Relation to mortality and later development of dementiaInternational Journal of Geriatric Psychiatry, 2006
- SEMANTIC DEMENTIABrain, 1992
- Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosisArchives of Gerontology and Geriatrics, 1987