Allostatic Load and Frailty in the Women's Health and Aging Studies
- 17 November 2008
- journal article
- research article
- Published by SAGE Publications in Biological Research For Nursing
- Vol. 10 (3), 248-256
- https://doi.org/10.1177/1099800408323452
Abstract
Background: Frailty involves decrements in many physiologic systems, is prevalent in older ages, and is characterized by increased vulnerability to disability and mortality. It is yet unclear how this geriatric syndrome relates to a preclinical cumulative marker of multisystem dysregulation. The purpose of this study was to evaluate whether allostatic load (AL) was associated with the geriatric syndrome of frailty in older community-dwelling women. Methods: We examined the cross-sectional relationship between AL and a validated measure of frailty in the baseline examination of two complementary population-based cohort studies, the Women's Health and Aging studies (WHAS) I and II. This sample of 728 women had an age range of 70—79. We used ordinal logistic regression to estimate the relationship between AL and frailty controlling for covariates. Results: About 10% of women were frail and 46% were prefrail. AL ranged from 0 to 8 with 91% of participants scoring between 0 and 4. Regression models showed that a unit increase in the AL score was associated with increasing levels of frailty (OR = 1.16, 95% CI = 1.04—1.28) controlling for race, age, education, smoking status, and comorbidities. Conclusion: This study suggests that frailty is associated with AL. The observed relationship provides some support for the hypothesis that accumulation of physiological dysregulation may be related to the loss of reserve characterized by frailty.Keywords
This publication has 42 references indexed in Scilit:
- Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older AdultsJournal of the American Geriatrics Society, 2006
- Long‐Term Risks of Death and Institutionalization of Elderly People in Relation to Deficit Accumulation at Age 70Journal of the American Geriatrics Society, 2006
- Cumulative biological risk and socio-economic differences in mortality: MacArthur Studies of Successful AgingSocial Science & Medicine, 2003
- IGF-1 receptor regulates lifespan and resistance to oxidative stress in miceNature, 2002
- Allostatic load as a predictor of functional declineJournal of Clinical Epidemiology, 2002
- Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia∗∗The opinions and assertions expressed herein are those of the authors and are not to be construed as reflecting the views of the USUHS or the US Department of Defense.The American Journal of Cardiology, 2002
- The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressureArchives of Internal Medicine, 1997
- Stress and the IndividualArchives of Internal Medicine, 1993
- Test-retest reliability of the Minnesota Leisure Time Physical Activity QuestionnaireJournal of Chronic Diseases, 1986
- Prediction of Creatinine Clearance from Serum CreatinineNephron, 1976