FOXO transcription factors: key regulators of cell fate
- 1 October 2006
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 34 (5), 722-726
- https://doi.org/10.1042/bst0340722
Abstract
FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FOXO proteins relies on their ability to control diverse and at times, opposing cellular functions, such as proliferation, differentiation, DNA repair, defence against oxidative stress damage and apoptosis, in response to hormones, growth factors and other environmental cues. This review discusses our current understanding of the regulation and role of FOXO transcription factors in determining cell fate and highlights their relevance to tumorigenesis and drug resistance.Keywords
This publication has 49 references indexed in Scilit:
- Regulation of the PTEN phosphataseGene, 2006
- FOXO transcription factors at the interface between longevity and tumor suppressionOncogene, 2005
- Blockade of Epidermal Growth Factor Receptors Chemosensitizes Breast Cancer Cells through Up-Regulation of Bnip3LCancer Research, 2005
- Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cellsOncogene, 2005
- FoxO3a and BCR-ABL Regulatecyclin D2Transcription through a STAT5/BCL6-Dependent MechanismMolecular and Cellular Biology, 2004
- p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1Proceedings of the National Academy of Sciences of the United States of America, 2004
- The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulationBiochemical Journal, 2004
- FOXO Proteins Regulate Tumor Necrosis Factor-related Apoptosis Inducing Ligand ExpressionPublished by Elsevier BV ,2002
- FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawalThe Journal of cell biology, 2002
- PHOSPHOINOSITIDE KINASESAnnual Review of Biochemistry, 1998