A dynamic study of viraemia in chronic hepatitis C infection
- 1 June 1994
- journal article
- research article
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 9 (3), 242-244
- https://doi.org/10.1111/j.1440-1746.1994.tb01717.x
Abstract
The dynamics of alanine aminotransferase (ALT), anti-hepatitis C virus and hepatitis C virus (HCV) RNA in six cases with chronic HCV infection were studied for 3-7 years. Two of the six cases showed continued elevation of ALT, and three showed intermittent elevation. All cases were persistently positive for anti-HCV after initial seroconversion. Five of the six cases were persistently positive for HCV RNA detected by nested polymerase chain reaction, and one was positive intermittently. Thus hepatitis C virus replicates continually in a majority of patients with chronic hepatitis C, although some cases may show intermittent replication, and replication of hepatitis C virus does not always correlate with elevated ALT.Keywords
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