The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders
Open Access
- 30 March 2011
- journal article
- review article
- Published by Hindawi Limited in Cardiovascular Psychiatry and Neurology
- Vol. 2011, 1-9
- https://doi.org/10.1155/2011/482415
Abstract
A wind of change characterizes epilepsy research efforts. The traditional approach, based on a neurocentric view of seizure generation, promoted understanding of the neuronal mechanisms of seizures; this resulted in the development of potent anti-epileptic drugs (AEDs). The fact that a significant number of individuals with epilepsy still fail to respond to available AEDs restates the need for an alternative approach. Blood-brain barrier (BBB) dysfunction is an important etiological player in seizure disorders, and combination therapies utilizing an AED in conjunction with a “cerebrovascular” drug could be used to control seizures more effectively than AED therapy alone. The fact that the BBB plays an etiologic role in other neurological diseases will be discussed in the context of a more “holistic” approach to the patient with epilepsy, where comorbidity variables are also encompassed by drug therapy.Keywords
Funding Information
- Cleveland Clinic-Swedish Satellite Laboratory (R01 NS060881, R01 NS43284, R01 NS38195, R21 HD057256)
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