Generalizability
- 5 June 2012
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 78 (23), 1886-1891
- https://doi.org/10.1212/wnl.0b013e318258f812
Abstract
Clinical and epidemiologic investigations are paying increasing attention to the critical constructs of “representativeness” of study samples and “generalizability” of study results. This is a laudable trend and yet, these key concepts are often misconstrued and conflated, masking the central issues of internal and external validity. The authors define these issues and demonstrate how they are related to one another and to generalizability. Providing examples, they identify threats to validity from different forms of bias and confounding. They also lay out relevant practical issues in study design, from sample selection to assessment of exposures, in both clinic-based and population-based settings.Keywords
This publication has 24 references indexed in Scilit:
- Smoking, Death, and Alzheimer DiseaseAlzheimer Disease & Associated Disorders, 2012
- Rotenone, Paraquat, and Parkinson’s DiseaseEnvironmental Health Perspectives, 2011
- Head injury and Parkinson's disease risk in twinsAnnals of Neurology, 2006
- Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football PlayersNeurosurgery, 2005
- Neuropsychological Functioning and Recovery after Mild Head Injury in Collegiate AthletesNeurosurgery, 1996
- Neuropsychological Functioning and Recovery after Mild Head Injury in Collegiate AthletesNeurosurgery, 1996
- Possible environmental, occupational, and other etiologic factors for Parkinson's diseaseNeurology, 1996
- Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control StudiesInternational Journal of Epidemiology, 1991
- Head trauma with loss of consciousness as a risk factor for Alzheimer's diseaseNeurology, 1989
- The Mortality of Doctors in Relation to Their Smoking HabitsBMJ, 1954