Association of Insulin Resistance, Hyperleptinemia, and Impaired Nitric Oxide Release With In-Stent Restenosis in Patients Undergoing Coronary Stenting
- 28 October 2003
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 108 (17), 2074-2081
- https://doi.org/10.1161/01.cir.0000095272.67948.17
Abstract
Background— Previously undiagnosed diabetes, impaired glucose tolerance, and insulin resistance are common in patients with acute myocardial infarction and coronary heart disease (CHD) and might be involved in early restenosis after stent implantation. To evaluate whether markers of insulin resistance syndrome, including leptin, and endothelial dysfunction are related to increased rate of early restenosis, we studied nondiabetic patients with CHD after successful coronary stenting.Keywords
This publication has 26 references indexed in Scilit:
- Impact of insulin resistance on neointimal tissue proliferation after coronary stent implantation: Intravascular ultrasound studiesJournal of Diabetes and its Complications, 2002
- Leptin Effect on Endothelial Nitric Oxide Is Mediated Through Akt–Endothelial Nitric Oxide Synthase Phosphorylation PathwayDiabetes, 2002
- Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin SensitivityDiabetes, 2001
- Insulin Sensitivity from Meal Tolerance Tests in Normal Subjects: A Minimal Model IndexJournal of Clinical Endocrinology & Metabolism, 2000
- Plasma nitric oxide concentrations are elevated in insulin-resistant healthy subjectsMetabolism, 2000
- Leptin induces direct vasodilation through distinct endothelial mechanisms.Diabetes, 2000
- Endothelial and metabolic characteristics of patients with angina and angiographically normal coronary arteries: Comparison with subjects with insulin resistance syndrome and normal controlsJournal of the American College of Cardiology, 1999
- Sample Pretreatment with Nitrate Reductase and Glucose-6-Phosphate Dehydrogenase Quantitatively Reduces Nitrate While Avoiding Interference by NADP+ When the Griess Reaction Is Used to Assay for NitriteAnalytical Biochemistry, 1995
- Toward Physiological Understanding of Glucose Tolerance: Minimal-Model ApproachDiabetes, 1989
- Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 1985