Highly Efficient Non-Biofouling Coating of Zwitterionic Polymers: Poly((3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide)
- 14 April 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 23 (10), 5678-5682
- https://doi.org/10.1021/la063737w
Abstract
This work describes the formation of highly efficient non-biofouling polymeric thin films of poly((3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide), (poly(MPDSAH)). The poly(MPDSAH) films were generated from the self-assembled monolayers terminating in an initiator of atom transfer radical polymerization (ATRP) by the surface-initiated ATRP of MPDSAH. The poly(MPDSAH) films on a gold surface were characterized by ellipsometry, FT-IR spectroscopy, contact angle goniometery, and X-ray photoelectron spectroscopy. The copper complexes and unpolymerized monomers trapped inside the polymer brushes were completely washed out by soaking the poly(MPDSAH)-coated substrate in water at 40 °C for 4 days. The amount of proteins nonspecifically adsorbed onto the poly(MPDSAH) films was evaluated by surface plasmon resonance spectroscopy: the adsorption of proteins was 2 on the surfaces for all the model proteins. The ability of the poly(MPDSAH) films to resist the nonspecific adsorption of proteins was comparable to that of the best known systems.This publication has 45 references indexed in Scilit:
- Formation of Superhydrophobic Surfaces by Biomimetic Silicification and FluorinationLangmuir, 2006
- Superlow Fouling Sulfobetaine and Carboxybetaine Polymers on Glass SlidesLangmuir, 2006
- Surface Grafted Sulfobetaine Polymers via Atom Transfer Radical Polymerization as Superlow Fouling CoatingsThe Journal of Physical Chemistry B, 2006
- UCST Wetting Transitions of Polyzwitterionic Brushes Driven by Self‐AssociationAngewandte Chemie-International Edition, 2006
- Highly Protein-Resistant Coatings from Well-Defined Diblock Copolymers Containing SulfobetainesLangmuir, 2006
- Phospholipid polymer surfaces reduce bacteria and leukocyte adhesion under dynamic flow conditionsJournal of Biomedical Materials Research Part A, 2005
- Protein Adsorption on Oligo(ethylene glycol)-Terminated Alkanethiolate Self-Assembled Monolayers: The Molecular Basis for Nonfouling BehaviorThe Journal of Physical Chemistry B, 2005
- Factors that Determine the Protein Resistance of Oligoether Self-Assembled Monolayers − Internal Hydrophilicity, Terminal Hydrophilicity, and Lateral Packing DensityJournal of the American Chemical Society, 2003
- Why do phospholipid polymers reduce protein adsorption?Journal of Biomedical Materials Research, 1998
- Interfacial Lifshitz-van der Waals and polar interactions in macroscopic systemsChemical Reviews, 1988