Defining Virulence Genes in the Dimorphic Fungi
- 1 October 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 60 (1), 281-303
- https://doi.org/10.1146/annurev.micro.59.030804.121055
Abstract
Most dimorphic fungal pathogens cause respiratory disease in mammals and must therefore possess virulence mechanisms to combat and overcome host pulmonary defenses. Over the past decade, advances in genetic tools have made it possible to investigate the basis of dimorphic fungal pathogenesis at the molecular level. Gene disruptions and RNA interference have now formally demonstrated the involvement of six virulence factors: CBP, α-(1,3)-glucan, BAD1, SOWgp, Mep1, and urease. Additional candidate virulence-associated genes have been identified on the premise that factors necessary for pathogenicity are associated specifically with the parasitic form. This principle continues to form the foundation for genomics-based analyses to further augment the list. Thus, the stage is set and the tools are in place for the next phase of medical mycology research: defining the virulence-associated factors underlying the success of dimorphic fungal pathogens.Keywords
This publication has 79 references indexed in Scilit:
- Identification ofHistoplasma capsulatumTranscripts Induced in Response to Reactive Nitrogen SpeciesMolecular Biology of the Cell, 2005
- Identification of genes preferentially expressed in the pathogenic yeast phase of Paracoccidioides brasiliensis, using suppression subtraction hybridization and differential macroarray analysisMolecular Genetics and Genomics, 2004
- Heterologous Expression, Purification, and Immunological Reactivity of a Recombinant HSP60 from Paracoccidioides brasiliensisClinical and Vaccine Immunology, 2002
- Identification, N-terminal region sequencing and similarity analysis of differentially expressed proteins in Paracoccidioides brasiliensisMedical Mycology, 1999
- Exocellular proteolytic activity of Paracoccidioides brasiliensis: cleavage of components associated with the basement membraneMedical Mycology, 1998
- Biolistic transformation of the human pathogenic fungus Coccidioides immitisJournal of Microbiological Methods, 1998
- Modulation of Immune Responses in Murine Pulmonary HistoplasmosisThe Journal of Infectious Diseases, 1997
- Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidisGene, 1997
- Isolation and characterization of the arginase-encoding gene (arg) from Coccidioides immitisGene, 1995
- Enhanced oxidative mechanisms in immunologically activated versus elicited polymorphonuclear neutrophils: correlations with fungicidal activityJournal of Medical Microbiology, 1988