Clinical and Biochemical Manifestations of Depression
- 18 August 1988
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 319 (7), 413-420
- https://doi.org/10.1056/nejm198808183190706
Abstract
(Second of Two Parts)Neurohormonal HypothesesThe cardinal biologic manifestations of major affective disorder consist of alterations in the hypothalamic centers that govern food intake, libido, circadian rhythms, and the synthesis and release of hypothalamic hormones into hypophysial portal blood and the systemic circulation. Patients with melancholia typically have anorexia, decreased sexual interest, altered timing of the cycle of rest and activity (i.e., early-morning awakening), diurnal variation in mood, and endocrine abnormalities such as hypercortisolism.4, 84 , 85 In a typical depression, the defining characteristics include hyperphagia and hypersomnia.8 The first neuroendocrine investigations into major affective disorder rested on the demonstration that monoaminergic . . .Keywords
This publication has 72 references indexed in Scilit:
- Mismatches between neurotransmitter and receptor localizations in brain: observations and implicationsNeuroscience, 1987
- Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axisBrain Research, 1984
- Influence of Corticotropin-Releasing Factor on Reproductive Functions in the Rat*Endocrinology, 1984
- Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female ratNature, 1983
- Corticotropin-Releasing Factor: Actions on the Sympathetic Nervous System and Metabolism*Endocrinology, 1982
- Intraventricular corticotropin-releasing factor enhances behavioral effects of noveltyLife Sciences, 1982
- Corticotropin releasing factor produces behavioural activation in ratsNature, 1982
- Hypothalamic hormones.Annual Review of Physiology, 1976
- Urinary free Cortisol excretion in depressionPsychological Medicine, 1976
- Cortisol Production in Depressive IllnessArchives of General Psychiatry, 1970