Coupling Microdroplet Microreactors with Mass Spectrometry: Reading the Contents of Single Droplets Online
- 28 April 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 48 (20), 3665-3668
- https://doi.org/10.1002/anie.200806103
Abstract
Fully integrated: Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 μm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on‐chip protein evolution and chemical synthesis.Keywords
This publication has 40 references indexed in Scilit:
- Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidicsLab on a Chip, 2008
- Microdroplets: A sea of applications?Lab on a Chip, 2008
- Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular OrganismsCell Chemical Biology, 2008
- Development of Quantitative Cell-Based Enzyme Assays in MicrodropletsAnalytical Chemistry, 2008
- An Integrated Device for Monitoring Time‐Dependent in vitro Expression From Single Genes in Picolitre DropletsChemBioChem, 2008
- Droplet microfluidicsLab on a Chip, 2008
- Miniaturizing chemistry and biology in microdropletsChemical Communications, 2007
- Reaktionen in MikrofluidiktröpfchenAngewandte Chemie, 2006
- Reactions in Droplets in Microfluidic ChannelsAngewandte Chemie-International Edition, 2006
- Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of ReagentsJournal of the American Chemical Society, 2003