Coronavirus Infections in the Central Nervous System and Respiratory Tract Show Distinct Features in Hospitalized Children
Top Cited Papers
Open Access
- 1 March 2016
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 59 (3), 163-169
- https://doi.org/10.1159/000453066
Abstract
Background/Aims: Coronavirus (CoV) infections induce respiratory tract illnesses and central nervous system (CNS) diseases. We aimed to explore the cytokine expression profiles in hospitalized children with CoV-CNS and CoV-respiratory tract infections. Methods: A total of 183 and 236 hospitalized children with acute encephalitis-like syndrome and respiratory tract infection, respectively, were screened for anti-CoV IgM antibodies. The expression profiles of multiple cytokines were determined in CoV-positive patients. Results: Anti-CoV IgM antibodies were detected in 22/183 (12.02%) and 26/236 (11.02%) patients with acute encephalitis-like syndrome and respiratory tract infection, respectively. Cytokine analysis revealed that the level of serum granulocyte colony-stimulating factor (G-CSF) was significantly higher in both CoV-CNS and CoV-respiratory tract infection compared with healthy controls. Additionally, the serum level of granulocyte macrophage colony-stimulating factor (GM-CSF) was significantly higher in CoV-CNS infection than in CoV-respiratory tract infection. In patients with CoV-CNS infection, the levels of IL-6, IL-8, MCP-1, and GM-CSF were significantly higher in their cerebrospinal fluid samples than in matched serum samples. Conclusion: To the best of our knowledge, this is the first report showing a high incidence of CoV infection in hospitalized children, especially with CNS illness. The characteristic cytokine expression profiles in CoV infection indicate the importance of host immune response in disease progression.Keywords
This publication has 38 references indexed in Scilit:
- Human coronavirus ocurrence in different populations of Sao Paulo: a comprehensive nine-year study using a pancoronavirus RT-PCR assayBrazilian Journal of Microbiology, 2013
- CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infectionPediatric Research, 2012
- Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR MethodJournal of Clinical Microbiology, 2010
- Cytokines and chemokines in viral encephalitis: A clinicoradiological correlationNeuroscience Letters, 2010
- Regulation of Proinflammatory Cytokine Expression in Primary Mouse Astrocytes by Coronavirus InfectionJournal of Virology, 2009
- The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in diseaseBlood, 2009
- Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infectionBlood, 2006
- Human coronavirus OC43 causes influenza-like illness in residents and staff of aged-care facilities in Melbourne, AustraliaEpidemiology and Infection, 2004
- Transgenic models to assess the pathogenic actions of cytokines in the central nervous systemMolecular Psychiatry, 1997
- IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway.JCI Insight, 1995