Neuronal circuitry for pain processing in the dorsal horn
Top Cited Papers
- 11 November 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Neuroscience
- Vol. 11 (12), 823-836
- https://doi.org/10.1038/nrn2947
Abstract
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.Keywords
This publication has 139 references indexed in Scilit:
- Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approachPain, 2010
- Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic inputNeuroscience, 2010
- A quantitative study of brainstem projections from lamina I neurons in the cervical and lumbar enlargement of the ratBrain Research, 2010
- Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal hornNeuroscience, 2009
- Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial areaJournal of Comparative Neurology, 2009
- Descending control of nociception: Specificity, recruitment and plasticityBrain Research Reviews, 2009
- Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABAA receptors from synapses in laminae I–II of the ipsilateral spinal dorsal hornNeuroscience, 2008
- A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cordJournal of Comparative Neurology, 2008
- Identity of myelinated cutaneous sensory neurons projecting to nocireceptive laminae following nerve injury in adult miceJournal of Comparative Neurology, 2008
- Topographically Distinct Epidermal Nociceptive Circuits Revealed by Axonal Tracers Targeted to MrgprdNeuron, 2005