Mesenchymal Stem Cell (MSC)‐Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine
- 5 June 2019
- journal article
- research article
- Published by Wiley in The Anatomical Record
- Vol. 303 (6), 1735-1742
- https://doi.org/10.1002/ar.24186
Abstract
Mesenchymal stem cells (MSCs) are pluripotent progenitor cells with the capabilities of self‐renewing, differentiating into multiple lineages, and achieving trophic effects during tissue repair. MSCs can secrete extracellular vesicles (EVs) including exosomes and microvesicles, which mediate their trophic effects on other cells. Carrying a variety of intracellular molecules of MSCs including lipids, proteins, RNA (mRNA and non‐coding RNA), and DNA, EVs deliver them into other cells to regulate tissue regeneration process. The therapeutic effects of MSC‐derived EVs have been observed in a number of animal disease models. In this review, we focus on the current state and future directions of MSC‐derived EVs in regenerative medicine.Keywords
Funding Information
- China Scholarship Council
- National Institute of General Medical Sciences (P20GM104937)
- National Natural Science Foundation of China (81371987)
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