Acute Corticospinal Tract Wallerian Degeneration Is Associated With Stroke Outcome
- 1 April 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 41 (4), 751-756
- https://doi.org/10.1161/strokeaha.109.573287
Abstract
Background and Purpose— In children with stroke, poor motor outcome is associated with early Wallerian degeneration of the corticospinal tract that is seen on diffusion-weighted MRI. In this study we test the hypothesis that early diffusion changes also occur in the corticospinal tract (CST) of adults after stroke and that these lesions are associated with poor outcome. Methods— In this retrospective study, we assessed images from a serial MRI study of adults with acute middle cerebral/internal carotid artery stroke. MRI-negative TIA patients served as controls. Custom software measured signal along the CST on different sequences, including the apparent diffusion coefficient (ADC). Visual detection of abnormal signal by blinded neuroradiologists was also evaluated. We then determined associations between CST signal changes and 3-month motor outcome (NIHSS score). Results— Thirty-eight patients (20 stroke/18 control) were included. ADC measures were much more accurate than other MRI sequences for detection of degeneration in the CST. The ADC decreased in a time-dependent fashion in the CST of patients with poor motor outcome but not in those with good outcome. Changes in ADC were maximal at 7 days. Neuroradiologists could visually detect these changes with accuracy comparable to the software method. Conclusion— CST ADC decreases after acute stroke in patients with poor motor outcome and may represent early Wallerian degeneration. Recognition of this imaging marker may improve early outcome prediction and patient selection for rehabilitation and neuroprotection trials.Keywords
This publication has 27 references indexed in Scilit:
- Corticospinal Tract Pre-Wallerian DegenerationStroke, 2009
- European PerspectivesCirculation, 2008
- Wallerian degeneration of the corticospinal tracts: postmortem MR–pathologic correlationsActa Radiologica, 2007
- Wallerian-Like Degeneration After Ischemic Stroke Revealed by Diffusion - Weighted ImagingCanadian Journal of Neurological Sciences, 2007
- Quantified Corticospinal Tract Diffusion Restriction Predicts Neonatal Stroke OutcomeStroke, 2007
- Prediction of Outcome in New-Born Infants with Arterial Ischaemic Stroke Using Diffusion-Weighted Magnetic Resonance ImagingNeuropediatrics, 2005
- MRI demonstration of Wallerian degeneration in various intracranial lesions and its clinical implicationsJournal of the Neurological Sciences, 1997
- Prediction of Outcome in Children with Congenital Hemiplegia: A Magnetic Resonance Imaging StudyNeuropediatrics, 1994
- Wallerian degeneration: evaluation with MR imaging.Radiology, 1988
- XX. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibresPhilosophical Transactions of the Royal Society of London, 1850