Brain-derived-neurotrophic-factor (BDNF) stress response in rats bred for learned helplessness
- 1 July 2001
- journal article
- Published by Springer Science and Business Media LLC in Molecular Psychiatry
- Vol. 6 (4), 471-474
- https://doi.org/10.1038/sj.mp.4000907
Abstract
Stress-induced elevation of glucocorticoids is accompanied by structural changes and neuronal damage in certain brain areas. This includes reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus which can be prevented by chronic electroconvulsive seizures and antidepressant drug treatment. In the last years we have bred two strains of rats, one which reacts with congenital helplessness to stress (cLH), and one which congenitally does not acquire helplessness when stressed (cNLH). After being selectively bred for more than 40 generations these strains have lost their behavioural plasticity including their sensitivity to antidepressant treatment. We show here that in cLH rats, acute immobilization stress does not induce a reduction of BDNF expression in the hippocampus which is observed in Sprague--Dawley and cNLH rats. All animals tested exhibited elevated corticosterone levels when stressed, an indication, that in cLH rats regulation of BDNF expression in the hippocampal formation is uncoupled from corticosterone increase induced through stress. This may explain the lack of adaptive responses in this strain.Keywords
This publication has 14 references indexed in Scilit:
- The Corticosteroid Receptor Hypothesis of DepressionNeuropsychopharmacology, 2000
- Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depressionNeuroReport, 2000
- Early Stress and Genetic Influences on Hypothalamic–Pituitary–Adrenal Axis Functioning in AdulthoodHormones and Behavior, 1999
- Increased basal activity of the HPA axis and renin‐angiotensin system in congenital learned helpless rats exposed to stress early in developmentInternational Journal of Developmental Neuroscience, 1999
- NEUROTROPHINS AND SYNAPTIC PLASTICITYAnnual Review of Neuroscience, 1999
- Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampusJournal of Neuroscience Research, 1997
- Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)Pharmacology Biochemistry and Behavior, 1997
- Neurotrophins and Neuronal PlasticityScience, 1995
- Rebound of aldosterone but not of corticosterone after suppression of adrenal function by triamcinolone acetonide in ratsClinical Science, 1988
- Diurnal Variation in Neuroendocrine Response to Stress in Rats: Plasma ACTH, β-Endorphin, β-LPH, Corticosterone, Prolactin and Pituitary Cyclic AMP ResponsesNeuroendocrinology, 1986