Cardiovascular fitness is associated with cognition in young adulthood
Open Access
- 8 December 2009
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 106 (49), 20906-20911
- https://doi.org/10.1073/pnas.0905307106
Abstract
During early adulthood, a phase in which the central nervous system displays considerable plasticity and in which important cognitive traits are shaped, the effects of exercise on cognition remain poorly understood. We performed a cohort study of all Swedish men born in 1950 through 1976 who were enlisted for military service at age 18 (N = 1,221,727). Of these, 268,496 were full-sibling pairs, 3,147 twin pairs, and 1,432 monozygotic twin pairs. Physical fitness and intelligence performance data were collected during conscription examinations and linked with other national databases for information on school achievement, socioeconomic status, and sibship. Relationships between cardiovascular fitness and intelligence at age 18 were evaluated by linear models in the total cohort and in subgroups of full-sibling pairs and twin pairs. Cardiovascular fitness, as measured by ergometer cycling, positively associated with intelligence after adjusting for relevant confounders (regression coefficient b = 0.172; 95% CI, 0.168–0.176). Similar results were obtained within monozygotic twin pairs. In contrast, muscle strength was not associated with cognitive performance. Cross-twin cross-trait analyses showed that the associations were primarily explained by individual specific, non-shared environmental influences (≥80%), whereas heritability explained <15% of covariation. Cardiovascular fitness changes between age 15 and 18 y predicted cognitive performance at 18 y. Cox proportional-hazards models showed that cardiovascular fitness at age 18 y predicted educational achievements later in life. These data substantiate that physical exercise could be an important instrument for public health initiatives to optimize educational achievements, cognitive performance, as well as disease prevention at the society level.Keywords
This publication has 57 references indexed in Scilit:
- Task-dependent Modulations of Prefrontal and Hippocampal Activity during Intrinsic Word ProductionJournal of Cognitive Neuroscience, 2009
- Aerobic fitness is associated with hippocampal volume in elderly humansHippocampus, 2009
- Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brainProceedings of the National Academy of Sciences of the United States of America, 2008
- Effects of acute exercise on executive processing, short-term and long-term memoryJournal of Sports Sciences, 2008
- Forced, not voluntary, exercise effectively induces neuroprotection in strokeActa Neuropathologica, 2008
- Effects of Aerobic Exercise on Overweight Children's Cognitive FunctioningResearch Quarterly for Exercise and Sport, 2007
- Exercise and Children’s Intelligence, Cognition, and Academic AchievementEducational Psychology Review, 2007
- Running induces widespread structural alterations in the hippocampus and entorhinal cortexHippocampus, 2007
- An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrusProceedings of the National Academy of Sciences of the United States of America, 2007
- Genetic Factors in Physical Activity and the Equal Environment Assumption – the Swedish Young Male Twins StudyBehavior Genetics, 2006