Prevalence and risk factors of hepatic steatosis and its impact on liver injury in Chinese patients with chronic hepatitis B infection
Open Access
- 18 August 2008
- journal article
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 23 (9), 1419-1425
- https://doi.org/10.1111/j.1440-1746.2008.05531.x
Abstract
The clinical significance of hepatic steatosis in chronic hepatitis B infection (CHB) is unclear. The aims of this study were thus to investigate the prevalence and risk factors for hepatic steatosis in patients with CHB and its relationship with liver injury.Consecutive patients with biopsy-proven CHB at Hangzhou Sixth People's Hospital between January 2005 and June 2007 were included. Patients co-infected with other viruses or suffering from liver disease of any other cause were excluded. Liver steatosis, necroinflammation and fibrosis were assessed by both Brunt and Scheuer classifications.A total of 1915 patients (1497 men) with a mean age of 31 +/- 9.5 years were analyzed. Hepatic steatosis was present in 260 (14%) patients. The steatosis involved < 33% of hepatocytes in 90% of cases, and was more frequent among men than women (15% vs 8%, P < 0.001). Two-thirds (178 of 260) of patients with steatosis were hepatitis B e antigen (HBeAg)-positive, but there was no correlation with either serum HBeAg status or hepatitis B virus DNA titer. Degree of inflammation and fibrosis were more mild among those with steatosis than those without. Multivariate analysis showed that steatosis was independently associated with body mass index, serum triglyceride, apolipoprotein B, uric acid, and fasting blood glucose. However, fibrosis was only independently associated with age and inflammatory grade, and the latter associated with viral load and fibrosis stage.Hepatic steatosis is common in CHB, it is associated with metabolic factors not viral ones, and does not appear to affect the severity of liver disease.Keywords
This publication has 37 references indexed in Scilit:
- Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokinesHepatology, 2007
- Non‐alcoholic fatty liver disease in the Asia–Pacific region: Definitions and overview of proposed guidelinesJournal of Gastroenterology and Hepatology, 2007
- Guidelines for the assessment and management of non‐alcoholic fatty liver disease in the Asia–Pacific region: Executive summaryJournal of Gastroenterology and Hepatology, 2007
- How common is non‐alcoholic fatty liver disease in the Asia–Pacific region and are there local differences?Journal of Gastroenterology and Hepatology, 2007
- What are the risk factors and settings for non‐alcoholic fatty liver disease in Asia–Pacific?Journal of Gastroenterology and Hepatology, 2007
- Global challenges in liver diseaseHepatology, 2006
- Nonalcoholic Fatty Liver Disease: From Steatosis to CirrhosisHepatology, 2006
- Prevalence of and risk factors for fatty liver in a general population of Shanghai, ChinaJournal of Hepatology, 2005
- Hepatic steatosis in chronic hepatitis B and C: Predictors, distribution and effect on fibrosisJournal of Hepatology, 2005
- Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndromeThe American Journal of Gastroenterology, 2003