A comparative evaluation of the metabolic profiles of normal and inflammatory knee‐joint synovial fluids by high resolution proton NMR spectroscopy
- 18 October 1993
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 332 (3), 221-225
- https://doi.org/10.1016/0014-5793(93)80636-9
Abstract
High resolution 1H NMR spectroscopy has been employed to investigate the metabolic profile of heatlhy human knee-joint synovial fluid (SF) and the biochemical data acquired have been compared with those of matched serum, and inflammatory knee-joint SF samples. Results obtained indicate that the healthy human knee-joint has a hypoxic status (high lactate level when expressed relative to that of paired serum) that is milder than that of the inflamed human knee-joint. Moreover, normal SF differs from that of inflammatory SF in that it contains little or no NMR-detectable lipoprotein-associated fatty acids and ‘acute-phase’ glycoproteins, an observation reflecting the limited passage of these macromolecules from plasma into the synovial space in healthy subjects.This publication has 11 references indexed in Scilit:
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