Subsequent Malignant Neoplasms in Cancer Survivors
- 1 November 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Cancer Journal
- Vol. 14 (6), 429-434
- https://doi.org/10.1097/ppo.0b013e31818d8779
Abstract
In the past 3 decades, the number of cancer survivors in the United States has tripled, reaching approximately 10.7 million in 2004. Although cancer survivors now comprise about 3.5% of the population, subsequent malignancies among this high-risk group account for about 16% (or 1 in 6) of all cancer incidence. Multiple primary cancers can reflect the influence of antecedent cancer therapy, shared etiologic factors, environmental exposures, genetic susceptibility, lifestyle choices, other factors, and the combinations of effects, including gene-environment and gene-gene interactions. Survivors of individual types of primary cancers are at increased risk for distinctive types of subsequent neoplasms. Careful documentation of the magnitude and temporal patterns of these site-specific excess risks, as well as delineation of the contribution of treatment exposures and other factors, will facilitate the development of optimal follow-up plans. Management approaches should include patient education, screening, and prevention strategies. An improved understanding of those malignancies that are largely treatment-related will facilitate the formulation of customized therapeutic approaches for newly diagnosed cancer patients aimed at minimizing the risk of subsequent neoplasms and other late effects, without compromising cure rates.Keywords
This publication has 65 references indexed in Scilit:
- Long-Term Solid Cancer Risk Among 5-Year Survivors of Hodgkin's LymphomaJournal of Clinical Oncology, 2007
- Risk of a second malignant neoplasm among 5‐year survivors of cancer in childhood and adolescence in British Columbia, CanadaPediatric Blood & Cancer, 2007
- Subsequent malignant neoplasms in survivors of childhood cancer: Childhood Cancer Survivor Study (CCSS) studiesPediatric Blood & Cancer, 2007
- Risk of second malignancies in long-term survivors of childhood cancerEuropean Journal Of Cancer, 2007
- Second malignancy risk associated with treatment of Hodgkin's lymphoma: meta-analysis of the randomised trialsAnnals of Oncology, 2006
- Cancer Survivorship—Genetic Susceptibility and Second Primary Cancers: Research Strategies and RecommendationsJNCI Journal of the National Cancer Institute, 2006
- Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factorsBlood, 2002
- Second Malignant Neoplasms Among Long-Term Survivors of Hodgkin’s Disease: A Population-Based Evaluation Over 25 YearsJournal of Clinical Oncology, 2002
- Second solid malignancies after combined modality therapy for Hodgkin's disease.Journal of Clinical Oncology, 1995
- Second solid tumors and leukemia after treatment for Hodgkin's disease: An analysis of 1121 patients from a single institutionInternational Journal of Radiation Oncology*Biology*Physics, 1994