Cationic Iron(III) Porphyrin-Catalyzed [4 + 2] Cycloaddition of Unactivated Aldehydes with Simple Dienes
- 19 March 2012
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (12), 5512-5515
- https://doi.org/10.1021/ja300790x
Abstract
Cationic iron(III) porphyrin was found to be an efficient catalyst for the highly chemoselective hetero-Diels–Alder-type reaction of aldehydes with 1,3-dienes. The catalyzed process did not require the use of electron-deficient aldehydes such as glyoxylic acid derivatives or activated electron-rich 1,3-dienes such as Danishefsky’s diene and Rawal’s diene. The high functional group tolerance and robustness of the catalyst were demonstrated. Further, the potential utility of the catalyst was demonstrated by performing the cycloaddition in the presence of water and by carrying out cycloaddition of an unactivated ketone such as cyclohexanone with a diene.Keywords
This publication has 38 references indexed in Scilit:
- A Four-Coordinate Fe(III) Porphyrin CationJournal of the American Chemical Society, 2008
- A DFT Study on Hetero‐Diels–Alder Reactions Catalyzed by Cobalt Complexes: Lewis Acidity Enhancement as a Consequence of Spin Transition Caused by Lewis Base CoordinationAngewandte Chemie-International Edition, 2005
- Catalytic Asymmetric Hetero-Diels–Alder Reactions of Carbonyl Compounds and IminesAngewandte Chemie-International Edition, 2000
- A “Magnetochemical” Series. Ligand Field Strengths of Weakly Binding Anions Deduced from S = 3/2, 5/2 Spin State Mixing in Iron(III) PorphyrinsJournal of the American Chemical Society, 1996
- The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosidesJournal of the American Chemical Society, 1987
- Totally Synthetic Routes to the Higher MonosaccharidesAngewandte Chemie-International Edition, 1987
- Hetero-Diels-Alder reaction in highly functionalized natural product synthesisAccounts of Chemical Research, 1986
- Coordinated hexafluoroantimonate: x-ray crystal structure of the intermediate-spin iron(III) tetraphenylporphinato complex Fe(TPP)(FSbF5).C6H5FInorganic Chemistry, 1985
- High threo diastereoselectivity via europium(III)-catalyzed cyclocondensation of a silyloxy diene with .alpha.-alkoxy aldehydes. Synthesis of (-)pestalotinJournal of the American Chemical Society, 1984
- Magnetic state of an unusual bacterial heme proteinThe Journal of Chemical Physics, 1974