An Attempt to Assess the Replacement Dose of Human Growth Hormone in the Treatment of Growth Hormone Deficient Children
- 1 July 1987
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 76 (s337), 87-92
- https://doi.org/10.1111/j.1651-2227.1987.tb17134.x
Abstract
In 25 patients with hGH deficiency, who had been treated long-term with hGH, the mode of hGH administration was switched from the conventional method (0.3-0.5 IU/kg/week, in two or three divided doses, intramuscularly) to daily subcutaneous injection at 1900-2100 hours with a dose of 0.46 +/- 0.07 IU/kg/week (equivalent to 14.7 +/- 2.0 IU/m2/week). After 1-3 months of this new mode of hGH administration, blood and urine were sampled at 0900 hours after overnight fasting. Blood glucose, plasma insulin, plasma IGF-1 and plasma total IGF (after extraction) were analysed in blood samples. IGF-1 and hGH were measured in urine samples. These measurements indicated that the dose studied was close to a replacement one, but might be slightly higher than the exact replacement dose.Keywords
This publication has 8 references indexed in Scilit:
- Is Growth Hormone Deficiency a Useful Diagnosis?Acta Paediatrica, 1987
- Treatment by hGH of Constitutional Delay of Growth and AdolescenceActa Paediatrica, 1986
- Demonstration of Human Growth Hormone in Normal Urine by a Highly Specific and Sensitive Sandwich Enzyme ImmunoassayAnalytical Letters, 1985
- Growth hormone neurosecretory dysfunction. A treatable cause of short staturePublished by American Medical Association (AMA) ,1984
- THE EFFECT OF BROMOCRIPTINE ON INSULIN SECRETION AND GLUCOSE TOLERANCE IN PATIENTS WITH ACROMEGALYClinical Endocrinology, 1981
- The use of a commercially available somatomedin-C radioimmunoassay in patients with disorders of growthThe Journal of Pediatrics, 1981
- Inhibition of Access of Bound Somatomedin to Membrane Receptor and Immunobinding Sites: A Comparison of Radioreceptor and Radioimmunoassay of Somatomedin in Native and Acid-Ethanol-Extracted Serum*Journal of Clinical Endocrinology & Metabolism, 1980
- Evaluation of Acromegaly by Radioimmunoassay of Somatomedin-CNew England Journal of Medicine, 1979