Cardiac responses to shock in curarized dogs: Effects of shock intensity and duration, warning signal, and prior experience with shock.

Abstract
In 6 curarizeddogs, the magnitudes of both the cardiac acceleration during shock stimulation and deceleration after stimulation were found to be monotonic increasing functions of intensity (2, 4, 6, and 8 ma. [milliampere ]); and inverted U -shaped functions of duration (0.1,0.5, 2.5, 5.0, and 10.0 sec.) of electrical shock. Utilizing 32 curarized dogs with a discriminative classical conditioning procedure, the presence of warning signal did not affect the magnitude of the unconditioned cardiac response, and previous experience with shocks of lower intensity did reduce the magnitude of the unconditioned cardiac response to subsequent high-intensity shock.