Oxalate nephropathy with a granulomatous lesion due to excessive intake of peanuts
- 1 August 2008
- journal article
- case report
- Published by Springer Science and Business Media LLC in Clinical and Experimental Nephrology
- Vol. 12 (4), 305-308
- https://doi.org/10.1007/s10157-008-0046-5
Abstract
A 65-year-old Japanese male developed renal dysfunction, showing proteinuria and marked urinary excretion of β2-microglobulin. He had consumed approximately 100–200 g peanuts and 750–1,000 ml beer every day for two or three months. He had previously been treated for hypertension with an angiotensin-converting enzyme inhibitor, enalapril. He then visited his primary-care doctor with mild fever, and renal dysfunction with mild diabetes mellitus were diagnosed. He was referred to our hospital, and because no diabetic retinopathy was observed by ophthalmological tests, renal biopsy examination was performed to clarify renal dysfunction. Renal biopsy specimens showed intimal thickening in the small arteries and interstitial nephritis with a granulomatous lesion, accompanied by oxalate crystals under polarized light. Glomeruli were unremarkable without any immunoglobulin deposition, and nodular lesions. Because he daily consumed a large amount of peanuts, oxalate nephropathy due to excessive intake of peanuts was strongly suspected. This case revealed that unusual food habits, including nuts, can cause oxalate nephropathy, and that close examination by renal biopsy was useful for clarifying the etiology of the unknown renal damage.Keywords
This publication has 14 references indexed in Scilit:
- Oxalate Intake and the Risk for NephrolithiasisJournal of the American Society of Nephrology, 2007
- Hyperoxaluria in Kidney Stone Formers Treated With Modern Bariatric SurgeryJournal of Urology, 2007
- Presentation and role of transplantation in adult patients with type 1 primary hyperoxaluria and the I244T AGXT mutation: Single-center experienceKidney International, 2006
- THE EFFICACY OF DIETARY INTERVENTION ON URINARY RISK FACTORS FOR STONE FORMATION IN RECURRENT CALCIUM OXALATE STONE PATIENTSJournal of Urology, 2005
- Fat malabsorption induced by gastrointestinal lipase inhibitor leads to an increase in urinary oxalate excretionKidney International, 2004
- Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studiesClinical and Experimental Nephrology, 2004
- Diagnostic and therapeutic strategies in hyperoxaluria: a plea for early interventionNephrology Dialysis Transplantation, 2004
- National trend of the incidence of urolithiasis in Japan from 1965 to 1995Kidney International, 1999
- Cutaneous oxalate granulomas in a haemodialysed patient: report of a case with unique clinical featuresBritish Journal of Dermatology, 1993
- Oxalate-induced acute renal failure in Crohn's diseaseAmerican Journal Of Medicine, 1980