Antidepressants and the Muscarinic Acetylcholine Receptor
- 1 February 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 34 (2), 236-239
- https://doi.org/10.1001/archpsyc.1977.01770140126014
Abstract
• Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.Keywords
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