Hypocholesterolesmic Effect of 4,4′-(Isopropylidenedithio)-Bis(2,6-di-t-Butylphenol) (Probucol)
Open Access
- 1 September 1970
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 23 (9), 1229-1233
- https://doi.org/10.1093/ajcn/23.9.1229
Abstract
Probucol (DH-581) is a lipophilic bisphenol that lowers serum cholesterol in several species. There is no effect on liver weight or liver cholesterol, and there is no consistent effect on serum and liver triglycerides. Incorporation of mevalonate-2-14C into cholesterol is not affected, indicating that probucol does not exert an influence on the late stages of biosynthesis. An inhibition of lipoprotein formation or transport is suggested.Keywords
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