Immune response to a DNA free herpes simplex vaccine in man
- 1 March 1982
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archiv für die gesamte Virusforschung
- Vol. 73 (1), 61-67
- https://doi.org/10.1007/bf01341728
Abstract
A DNA-free subunit herpes simplex virus (HSV) vaccine was administered to 15 volunteers without past evidence of HSV infection and to 25 patients with severe recurrent HSV infection. The immune response to the vaccine in these patients was compared to the immunological status of 20 non-vaccinated control patients with recurrent HSV infection. The vaccine elicited antibody and cell-mediated immunity (CMI) in the 15 subjects without past evidence of HSV infection and this response was similar to that observed after a natural infection. Among the 25 patients who were suffering from recurrent HSV infection the vaccine elicited complement dependent cytotoxic antibodies in 13 of these patients who did not possess these antibodies and increased significantly the titers of these antibodies in the 12 other patients. The vaccine gave a significant increase of the titers of the other specific antibodies as well as the level of cell-mediated immunity. The increase of the immunity level in these latter patients was not due to normal variations since in the non-vaccinated control group the antibody titers and CMI remained stable during the same period of time.This publication has 13 references indexed in Scilit:
- Efficacy of a virion envelope herpes simplex virus vaccine against experimental skin infections in hairless miceArchiv für die gesamte Virusforschung, 1981
- Efficacy of a nucleic acid free herpetic subunit vaccineArchiv für die gesamte Virusforschung, 1980
- Antibody and cell-mediated immunity to a DNA free herpes simplex subunit vaccine.1979
- Herpes Simplex Virus VaccinesThe Journal of Infectious Diseases, 1977
- Comparison of the humoral and cellular immune responses after immunization with live, UV inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunizationsArchiv für die gesamte Virusforschung, 1976
- Herpes simplex vaccines.1976
- VIRAL-ANTIBODY DETECTION BY A MORE SENSITIVE COMPLEMENT-FIXATION REACTIONThe Lancet, 1974
- A Micro-Mixed Leukocyte Culture Technique using Whole BloodInternational Archives of Allergy and Immunology, 1972
- Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytesCellular Immunology, 1970
- Herpesvirus Type 2: Association with Carcinoma of the CervixScience, 1968