Early Vasoactive Drugs Improve Heart Failure Outcomes
Open Access
- 11 November 2009
- journal article
- Published by Wiley in Congestive Heart Failure
- Vol. 15 (6), 256-264
- https://doi.org/10.1111/j.1751-7133.2009.00112.x
Abstract
Vasoactive therapy is often used to treat acute decompensated heart failure (ADHF). The authors sought to determine whether clinical outcomes are temporally associated with time to vasoactive therapy (vasoactive time) in ADHF. Using the Acute Decompensated Heart Failure (ADHERE) Registry, the authors examined the relationship between vasoactive time and inpatient mortality within 48 hours of hospitalization. Vasoactive agents were used early (defined as <6 hours) in 22,788 (63.8%) patients and late in 12,912 (36.2%). Median vasoactive time was 1.7 and 14.7 hours in the early and late groups, respectively. In-hospital mortality was significantly lower in the early group (odds ratio, 0.87; 95% confidence interval, 0.79-0.96; P=.006), and the adjusted odds of death increased 6.8% for every 6 hours of treatment delay (95% confidence interval, 4.2-9.6; P<.0001). Early vasoactive initiation is associated with improved outcomes in patients hospitalized for ADHF.Keywords
This publication has 19 references indexed in Scilit:
- Heart Disease and Stroke Statistics—2006 UpdateCirculation, 2006
- Acute Heart Failure SyndromesCirculation, 2005
- Relation between Diuretic Dose and Outcome in a Heart Failure Population: Results of the ESCAPE TrialJournal of Cardiac Failure, 2005
- Tezosentan in patients with acute heart failure: Design of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Study (VERITAS)American Heart Journal, 2005
- In-Hospital Mortality in Patients With Acute Decompensated Heart Failure Requiring Intravenous Vasoactive Medications: An Analysis From the Acute Decompensated Heart Failure National Registry (ADHERE)Journal of the American College of Cardiology, 2005
- Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)American Heart Journal, 2005
- Relationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY.American Heart Journal, 2004
- Ongoing right ventricular hemodynamics in heart failureJournal of the American College of Cardiology, 2003
- Neurohormonal activation rapidly decreases after intravenous therapy withdiuretics and vasodilators for class IV heart failureJournal of the American College of Cardiology, 2002
- Robust Locally Weighted Regression and Smoothing ScatterplotsJournal of the American Statistical Association, 1979