Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations
Open Access
- 17 June 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 11 (1), 79
- https://doi.org/10.1186/1465-9921-11-79
Abstract
Current methods for assessing clinical outcomes in COPD mainly rely on physiological tests combined with the use of questionnaires. The present review considers commonly used outcome measures such as lung function, health status, exercise capacity and physical activity, dyspnoea, exacerbations, the multi-dimensional BODE score, and mortality. Based on current published data, we provide a concise overview of the principles, strengths and weaknesses, and discuss open questions related to each methodology. Reviewed is the current set of markers for measuring clinically relevant outcomes with particular emphasis on their limitations and opportunities that should be recognized when assessing and interpreting their use in clinical trials of COPD.Keywords
This publication has 93 references indexed in Scilit:
- Development and first validation of the COPD Assessment TestEuropean Respiratory Journal, 2009
- Effects of Lung Volume Reduction Surgery on Gas Exchange and Breathing Pattern During Maximum ExerciseChest, 2009
- Cardiorespiratory risk factors as predictors of 40-year mortality in women and menHeart, 2009
- A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary DiseaseNew England Journal of Medicine, 2008
- Longitudinal Change in the BODE Index Predicts Mortality in Severe EmphysemaAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Sensor Acceptance Model – Measuring Patient Acceptance of Wearable SensorsMethods of Information in Medicine, 2008
- Field Tests of Exercise in COPD: The Six-Minute Walk Test and the Shuttle Walk TestCOPD: Journal of Chronic Obstructive Pulmonary Disease, 2007
- Physiology and consequences of lung hyperinflation in COPDEuropean Respiratory Review, 2006
- Inhaled corticosteroids and mortality in chronic obstructive pulmonary diseaseThorax, 2005
- Roflumilast for chronic obstructive pulmonary diseaseThe Lancet, 2005