Hepatitis B: changing epidemiology and interventions
- 16 December 2016
- journal article
- review article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 102 (7), 676-680
- https://doi.org/10.1136/archdischild-2016-312043
Abstract
Hepatitis B virus infection is still a major public health problem worldwide, since more than 350 million people have chronic, lifelong infection and nearly 1 million deaths occur each year owing to complications. Most infections are acquired at birth or during early childhood. Nowadays, low- and middle-income countries bear the majority of the burden of hepatitis B-related liver cancer deaths despite the availability of an effective vaccine and antiviral treatments. In this review the epidemiology, strategies of prevention and the recent advances in therapy, genotype diversity and resistance are discussed.Keywords
This publication has 22 references indexed in Scilit:
- Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trialsThe Lancet, 2015
- Progress in the Control of Hepatitis B Virus Infection among Children in IndonesiaJournal of Vaccines & Vaccination, 2014
- Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelinesJournal of Hepatology, 2013
- Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010The Lancet, 2012
- Chronic hepatitis B in children and adolescentsJournal of Hepatology, 2012
- Randomized, placebo-controlled trial of tenofovir disoproxil fumarate in adolescents with chronic hepatitis BJournal of Hepatology, 2012
- Effects of Maternal Screening and Universal Immunization to Prevent Mother-to-Infant Transmission of HBVGastroenterology, 2012
- Secular trend of the viral genotype distribution in children with chronic hepatitis B virus infection after universal infant immunizationJournal of Hepatology, 2010
- Long-term protection of hepatitis B vaccine 18 years after vaccinationJournal of Infection, 2008
- Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis BJournal of Hepatology, 2006