Thalidomide in 42 Patients with Prurigo Nodularis Hyde
- 24 September 2011
- journal article
- Published by S. Karger AG in Dermatology
- Vol. 223 (2), 107-112
- https://doi.org/10.1159/000331577
Abstract
The aim of this study was to describe the use of thalidomide in the treatment of prurigo nodularis Hyde (PNH) refractory to other treatments or in cases where other treatments cannot be used due to side effects. 77 medical records were retrospectively reviewed for the following data: sex, age, age at the beginning of thalidomide treatment, dermatological diagnosis, duration of the skin disease, previous treatments, indications for treatment with thalidomide, effect of treatment, duration of treatment with thalidomide, reasons for cessation of thalidomide treatment, and side effects. 54 patients had PNH. All patients were refractory to standard therapy or had side effects to treatment. 42 patients were treated with thalidomide and the majority of patients experienced clinical improvement. The most common reason for discontinuation of therapy was side effects, the most frequent being peripheral neuropathy and sedation. Thalidomide effectively treats PNH refractory to standard medications. However, physicians must be aware of possible side effects, especially peripheral neuropathy.Keywords
This publication has 14 references indexed in Scilit:
- Innovative Uses of ThalidomideDermatologic Clinics, 2010
- Dermatologic therapeutics: thalidomide. A practical guideDermatologic Therapy, 2007
- Thalidomide: An experience in therapeutic outcome and adverse reactionsJournal of Dermatological Treatment, 2007
- Thalidomide for dermatology: a review of clinical uses and adverse effectsInternational Journal of Dermatology, 2005
- Thalidomide: an old drug with new clinical applicationsExpert Opinion on Drug Safety, 2004
- Dermatologic and Nondermatologic Uses of ThalidomideAnnals of Pharmacotherapy, 2003
- Thalidomide in dermatologyAustralasian Journal of Dermatology, 2002
- Incidence and Risk Factors for Thalidomide Neuropathy: a Prospective Study of 135 Dermatologic PatientsJournal of Investigative Dermatology, 2002
- THALIDOMIDEDermatologic Clinics, 2001
- Rediscovering thalidomide: A review of its mechanism of action, side effects, and potential usesJournal of the American Academy of Dermatology, 1996