Philadelphia positive acute leukaemia with minor breakpoint cluster rearrangement may be a stem cell disease
- 1 May 1992
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 81 (1), 77-80
- https://doi.org/10.1111/j.1365-2141.1992.tb08175.x
Abstract
The biology of Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia (ALL) is the subject of much interest. We present a case of Ph+ ALL with a minor breakpoint cluster (mBCR) rearrangement who subsequently relapsed with Ph+ mBCR+ acute myeloid leukaemia and later with Ph+ mBCR+ acute stem cell leukaemia. This case provides further evidence that Ph+ ALL with a mBCR rearrangement may arise from a pluripotent stem cell with similar potential to that of chronic granulocytic leukaemia to undergo blastic crises with differing lineage characteristics.Keywords
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