Continuum of overlapping clones spanning the entire human chromosome 21q
- 1 October 1992
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 359 (6394), 380-387
- https://doi.org/10.1038/359380a0
Abstract
A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and ends with subtelomeric loci of 21q. The resulting order of sequence-tagged sites is consistent with other physical and genetic mapping data. This set of overlapping clones will promote our knowledge of the structure of this chromosome and the function of its genes.Keywords
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